Did Albert Hofmann actually bike home from the lab on that day or did someone help him? The 25 does not have any chemical meaning and ‘LSD’ and ‘LSD-25’ are the same. LSD-25 was the laboratory designation Albert Hofmann gave to LSD since it was the 25 th ergot alkaloid he synthesized. The version of LSD which is not a salt is called LSD freebase. To balance out the charge, most alkaloidal drugs are made into a salt, which means an acid is added to neutralize the part of the molecule that is a base. LSD is an alkaloid, a compound which contains a basic nitrogen. On the first Bicycle Day, Albert Hofmann took 250mcgs of LSD tartrate. Hofmann ingested 250mcgs of LSD tartrate.)ģ. This is further complicated by the fact that 100 micrograms of different LSD salts vary in potency by weight. *(Please note blotter tabs are not standardized and therefore it is should not be assumed that any street LSD blotter contains 100 micrograms of LSD. 25mgs of LSD or 250 micrograms, the equivalent of 2.5 standard* blotter tabs. No, he took a fairly common, although powerful dose by today’s standards. It is often claimed that Albert Hofmann took a very large dose of LSD on April 19 th 1943, the day known as Bicycle Day, the first time Hofmann purposefully ingested LSD. Its close chemical relative LSA, however, is found being produced by endophytic fungi living in species of Morning Glories and of Hawaiian Baby Woodrose.Ģ. This natural product, ergotamine, is then used as the first step in a chemical synthesis to make LSD, which itself is not known to be found in nature*. The fruiting bodies grow on a structure called a sclerotium, which are harvested, ground up, and extracted to get ergot alkaloids (nitrogen containing compounds), one of which is ergotamine. This fungus, ergot (claviceps purpurea), produces fruiting bodies like other mushrooms do. This natural precursor is called ergotamine and is a dimer (two molecules linked together) derived from a fungus that grows on rye. LSD is often considered a semi-synthetic drug because it is made from a natural precursor.
Here we will tackle some of those questions and see if we can’t straighten up the confusion. Today being Bicycle Day, we wanted to take the opportunity to clear up some confusion in psychedelic culture surrounding LSD.
After taking the LSD, Hofmann began to feel sickly and decided to ride his bicycle home from his laboratory at Sandoz Pharmaceuticals April 19 th is now celebrated in the psychedelic community worldwide as Bicycle Day. The compound, which he had invented 5 years earlier, would come to change the world. On April 19 th, 1943 in Basil, Switzerland, chemist Albert Hofmann took the world’s first trip on LSD.
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